Hypereosinophilia associated with dysplastic features and a constitutional translocation previously not described.

marrow examination actually showed relative erythroid hypoplasia. Many patients with homozygous thalassemia have intense erythropoietic marrow activity, with M:E ratios of 1:20. Thus, in this case, a M:E ratio of 1:8 may not truly reflect hyperplasia relative to this child’s baseline condition. Due to the different results reported in the immunohematologic studies, a definite explanation about the mechanism of B19-AIHA is still lacking. Some authors have reported a positive Donath-Landsteiner test after B19-AIHA.5 This was not found in our patient. We believe that evidence of acute B19 infection should be sought in patients with AIHA, particularly when associated with reticulocytopenia. Likewise, B19 should be listed among the viral illness associated with acute AIHA.